Dimenhydrinate is an anti-emetic drug which prevents nausea, vomiting and dizziness. It under goes extensive first pass metabolism and it shows variable absorption from GIT. The aim of the present investigation was to develop bilayer caplet dosage form of dimenhydrinate containing combination of immediate and sustained release layers. Dimenhydrinate bilayer caplets were prepared by wet granulation technique. Prepared granules as well as caplets were evaluated for various in-vitro and in-vivo studies. Bilayer caplets were formulated using hydrophilic polymer i.e. HPMC K 4M and the release sustained for a period of 12 hours. Optimized formulation was subjected for in-vivo studies in rabbits. From this research work it was evident that the developed formulation was able to sustain the drug release.
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